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SLEEP
Clinical
One third of the population suffers with some variety
of sleep disorder, making it one of the largest unmet medical
needs, the lack of effective treatment suppressing the
active demands from patients. Currently the principle therapy
for many sleep conditions are the benzodiazepines. These
are effective in the short term, but require escalating
doses and are highly addictive.
Relatively few clues exist as to how to design effective
therapies for sleep. Indeed, despite being a pervasive
phenomenon in the animal kingdom, including in birds, fish
and invertebrates, the function of sleep remains elusive.
Why does the animal kingdom render itself more vulnerable
to attack, every day, or night, by entering a period of
decreased environmental responsiveness ?
DanioLabs approach
Sleep disturbances are broken down into a number of different
categories, but ultimately the patient just wants 3 things:
1. To fall asleep at the right time.
2. To stay asleep.
3. To wake up refreshed.
DanioLabs strategy is to give the patient
these 3 things. The prime focus is on the overall symptomatology – what
makes the patient feel better, and not on a biochemical
of physiological parameter per se. It is of no comfort
to the sleep disturbed patient that a drug has increased
his delta wave activity if he doesn’t feel more refreshed
in the morning. Indeed, the EEG is an epiphenomenon of
sleep, a crude representation of neocortex activity, and
should be viewed as such.
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