Modelling Data

The fitting or modelling of single or repeat dose pharmacokinetic concentration-time and effect data can be performed easily using PCModfit. The program utilises two very different and powerful algorithms (both very fast) for generating the lines of 'best fit' through data with extensive predictive output to text files and with high quality graphics. Weighted and Iteratively Reweighted Least Squares approaches are used (with or without constraints) with inbuilt calculation of parameter errors and other such essential information required by any professional pk package. The graphical output is of high quality and these pictures, stored as metafiles, can be imported into Microsoft Word etc. Data can be entered into spreadsheets such as Microsoft Excel in columns and transferred to PCModfit in seconds. Summary results can be exported back to spreadsheets via the clipboard.

There are currently over 100 models built into the program including for example, i.v. bolus and infusion (up to 3-compartments), oral (first and zero order), various pk/pd functions, polynomials and many others to wet your appetite! A few examples of pictures generated from fitting data are shown for interest.